The Photothermal/Chemo-therapy Of Multifunctional Porous Materials Based On Tumor Microenvironment Regulation

The synergistic photothermal therapy has developed as one of the most attractive strategies for anti-tumor.The key is to design an effective photothermal platform to enhance the synergistic cancer therapy effect.The multifunctional nanomaterials are widely used in the tumors diagnosis and treatment by combining with functional drugs.The high temperature in the tumor produce a large number of ROS,which induce autophagy and apoptosis.Meanwhile,they have highly therapeutic effect and application prospect.However,the inflammatory not only hinders the following treatment,but also promotes the proliferation of the tumor by inducing angiogenesis,destroying the adaptive immunity,and activating invasion and metastasis.Hypoxia not only inhibits the expression of cytotoxic T cells,but also promotes immunosuppression.Based on photothermal nanomaterials,this dissertation significantly improves the therapeutic effect of tumor by regulating the complex microenvironment of tumor.The main contents are described as below:1.A multifunctional nanoplatform was designed based on mesoporous carbon nanoparticles,grafting with anti-inflammatory drug(celecoxib)and loading chemotherapy drug(doxorubicin).The constructed nanoplatform mesoporous carbon/celecoxib@doxorubicin was found to capable of,induce intravascular thrombosis,blocking nutrient supply for tumor,and over-inflammatory suppression avoiding acute tissue necrosis.Meanwhile,this study demonstrates combined chemo-and photothermal therapy and exhibits a promising potential in cancer therapy.2.Preparation of Au/Zn_0.4Fe_2.6@Zif-8/DOX/anti-ANG2(AFZDA),which can repair abnormal tumor blood vessels and increase blood perfusion.Espescially,the effect of T cells significantly are improved in the tumor tissue.The growth of tumor cells are inhibited by inducing the production of a large number of ROS and causing DNA damage in cells.In addition,the nanocomposite has a great application prospect in multi-mode real-time imaging of tumors.3.The concentration of oxygen in microenvironment of tumor are improved by high oxygen breathing,so as to promote the therapeutic effect of chemotherapy.Hypoxia promotes the proliferation and metastasis of tumor cells by interfering with physiological immune regulation.High oxygen breathing combined with nano-treatment reduce the accumulation of adenosine in cells and the expression of CD73 to aviod the immunosuppressive.Multifunction nanomaterials realize the photothermal/chemotherapy synergy through the regulation of tumor microenvironment.The tumor tissue inflammation,vascular abnormalities and oxygen microenvironment have been improve.The cancer cells cause autophagy and apoptosis producing a lot of ROS.Drug resistance and metastasis has been inhibited.The application prospect of multifunction nanomaterials is remarkable.