Near-infrared Light-triggered Cu_2-xS Plasma Effect For Water Treatment And Tumor Therapy

The continuous emergence of new pollutants leads to the scarcity of clean water resources and the occurrence of cancer,allergies and immune system-related diseases,posing a serious threat to human health.The technologies such as solar photocatalytic oxidation degradation of pollutants,seawater desalination and ultraviolet disinfection are expected to alleviate the problem of water shortage.However,the utilization of sunlight,especially near infrared(NIR,780?2526 nm)light,is insufficient at present.NIR absorbing materials have a good response to NIR light,so it is of great significance to develop NIR light-responsive materials and improve their utilization.The self-doped copper chalcogenide(Cu_2-xS)plasmon is not only cheap and easy to obtain,but also exhibits strong localized surface plasmon resonance(LSPR)absorption in the NIR region,which makes it have great application potential in environmental remediation and disease treatment.Based on this,this paper takes Cu_2-XS plasmon as the research object to carry out the following researches:(1)The NIR light-responsive Cu S-polyimide flexible composite membrane was constructed in a controllable way,and its application in seawater desalination with high-efficiency NIR photothermal conversion was explored.The membrane can not only regulate its NIR absorption by changing the amount of PVP during the synthesis of Cu S,but also exhibits extremely high photothermal conversion efficiency and thermal stability under NIR light irradiation.Under 808 nm laser irradiation,seawater desalination can be achieved,the water evaporation efficiency is about 80%with good cyclic evaporation stability.(2)Cu S nanosheets with excellent NIR performance were controllably synthesized by hydrothermal method,and the degradation performance of organic pollutants by NIR light enhanced Fenton-like reaction was explored.NIR photo Fenton-like and photothermal effect can enhance the activity of Cu S nanosheet reaction sites,improve the efficiency of heterogeneous reaction,and accelerate the degradation of pollutants.Under 1064 nm laser irradiation,4-CP was degraded completely within 15 min,with wide p H adaptability and certain reusability.(3)Self-doped Cu₉S₈ hollow nanospheres were constructed by solvothermal method,and the mechanism of NIR-II photo Fenton-like reaction and its antitumor effect were investigated.This work proves that NIR-II light can accelerate Cu(II)/Cu(I)conversion and improve the Fenton-like reaction efficiency based on the LSPR effect of Cu₉S₈ plasmon.Combined with the strong tissue penetration of NIR-II light,NIR-II photo Fenton-like reaction of Cu₉S₈ not only improves the therapeutic effect of tumor,but also avoids the photothermal damage to normal tissues.(4)The immunosensitization effect of NIR-II photo Fenton-like reaction was investigated.The Cu₉S₈ plasmon-mediated NIR-II photo Fenton-like reaction selectively kills tumor cells,modulates tumor immune microenvironment,and enhances the effect of immunotherapy.In vitro and in vivo results showed that this reaction effectively induces cellular immunogenic death,promotes dendritic cell maturation,thereby modulating tumor immune microenvironment,improving anti-tumor immune response,and effectively inhibiting primary and distant tumor as well as lung metastasis in combination of anti-PD-L1.In summary,based on the remediation of water environment and tumor treatment,this paper designed three kinds of Cu_2-xS composite nanomaterials with plasmonic effect,and carried out researches on the seawater desalination,chlorophenol pollutants degradation and anti-tumor therapy.The obtained Cu_2-xS composites exhibite good NIR response performance,and promote the utilization of NIR light effectively,which has good application prospect.