Research On Self-Powered Disease Treatment Microsystems

The rapid development of worldwide intelligent medical electronic devices is driving advancements in field of precision healthcare.Although the current medical electronic devices are powerful,inherent limitations hinder their interaction with the humans.To further promote the development of intelligent medical systems that can be worn or implanted in the body,we should focus on methods of power supplying in the system.Self-powered technology efficiently converts external energy into the electrical energy required by the system,without external power sources.This concept is considered the most promising alternative technology to address the drawbacks of traditional energy sources,especially for microelectronics that are difficult to power continuously through conventional means,particularly in the research of biomedical electronic devices.This technology can be combined with microelectronics and other technologies to construct a powerful self-powered disease treatment microsystem.In this paper,we introduce the concept of self-powered into intelligent disease treatment systems,simplify the operation of systems using external wireless control modes,and create multifunctional integrated self-powered disease treatment microsystems.We delve into the applications of selfpowered disease treatment microsystems in medical fields such as neural modulation,cancer treatment,and antimicrobial therapy.The specific research contents are as follows:1.Research on self-powered brain probe microsystems for inhibiting epileptic.We develop a self-powered mini-invasive brain probe microsystem for remote intelligent neuroregulation.The system can be wirelessly powered and controlled by cellphone audio tones(through piezoelectric effect)with the assistance of artificial intelligence cellphone video analysis.The system consists of a biocompatible pedestal integrated with microscale implanting stimulation electrodes connected to embedded magnets and a magnetically coupled custom-designed signal-intensifying resonator integrated with a piezoelectric powered signal modulation circuit.A programmed audio tone functions as the wireless power source,and it can be tele-transmitted remotely from other cellphones with desired neural stimulation protocols.Combined with artificial intelligence-enabled video monitoring of the epileptic tremor,we show that the probe can relieve the seizure events in the epileptic mice,and the therapeutic effect is confirmed by in-vivo electroencephalography and free-moving scenario.The multifunctionality of versatility,artificial intelligence-assistance,wireless power transfer,and tele-transmission of the cellphoneinteracted self-powered brain probe microsystem opens the possibility for remote precision neural modulation.2.Research on the self-powered therapeutic pellet microsystem for tumor treatment.We develop an implantable self-powered therapeutic pellet microsystem that provides photodynamic/sonodynamic hybrid therapy for low-dose/long-term cancer recurrence inhibition and tumor regression.The miniature pellet contains an integrated self-powered unit,microscale light-emitting diode illuminant,and control circuit.The system is powered by ultrasound energy via the piezoelectric effect.The pellet can deliver therapeutic doses of light into tissues for photodynamic therapy alongside direct sonodynamic therapy.The photodynamic/sonodynamic hybrid therapy is shown to be highly efficient in the treatment of breast cancer in mice in vivo.The system can operate successfully inside the body,and optimized sensitizer activation and wireless control of therapeutic dosimetry mean that it has great potential for cancer treatment.3.Research on the multifunctional self-powered therapeutic chip microsystem for antibacterial treatment.We develop a new implantable self-powered therapeutic chip microsystem integrated with light/drug unit for photodynamic therapy to achieve antibacterial treatment of bacterial liver abscesses.The microsystem is mainly composed of self-powered units,energy management units,specific wavelength micro-LED arrays,multiple drug microneedle arrays,and flexible biocompatible packaging.Due to its small size and good flexibility,it can be implanted near the target area.The therapeutic chip is powered by ultrasound energy via the piezoelectric effect.This self-powered therapeutic chip microsystem demonstrates effective antibacterial treatment in vitro antibacterial model and can be further developed for antibacterial treatment of bacterial liver abscesses in vivo.