In-Hospital Mortality Of Lung Cancer Higher Than Non-Cancerous Critically Ill Patients Following ICU Discharge

Objective:The goal of our research is comparison of in-hospital mortality between lung cancer and other non-cancerous critically ill patients following discharge of intensive care unit.Methods and materials:We collected our patients population from Medical Information Mart for Intensive Care Ⅳ(MIMIC-Ⅳ)database.The study population were divided into two group;lung cancer group and non-cancerous critically ill patients group.We compared in-hospital mortality rates in between these two groups after Propensity score matching(PSM).We compared the median and IQR of normally distributed variables by using the Mann-Whitney U test.Categorical variables labeled as percentages were compared using the chi-squared test.The in-hospital mortality,first ICU mortality were compared using chi-square test.Results:About 20425 clinical records from the MIMIC-Ⅳ database were studied.The lung cancer group and the non-cancer group included respectively 250 patients and 20175 patients.After propensity score matching,236 lung cancer patients were matched with 1094 non-cancerous critically ill patients.Following PSM,the differences of the age,ethnicity,Charlson comorbidity index,sofa score,height,weight,CRRT ventilation between lung cancer patients and no cancer patients were balanced.As for commodities,MI,congestive heart failure,chronic pulmonary disease,diabetes,renal disease and liver disease(all P<0.001)are significant after PSM.Besides,higher in-hospital mortality in the lung cancer group than in the non-cancer group 0.19 versus 0.12,P-value 0.013,that indicated higher in-hospital mortality among lung cancer patients.No difference was found for mortality in first ICU.Conclusion:In-hospital mortality rate is higher in all types of lung cancer in comparison with critically ill-patients without cancer after discharge from an intensive care unit.