Studies On The Interaction Of Organotin Compounds With Natural Amino Acid

Amino acid is fundamental unit of protein, which plays an important role in life activity of biology. With the complex cisplatin being clinically used in cancer chemotherapy in the late 1960s, metal complexes have attracted much attention as a new type of potential anticancer drugs.In recent years, a variety of studies have been carried out on the anticancer of the compounds organogermanium and the compounds organotin , which have the similar biomedical activity to the cisplatin. Especially, the compounds of organogermanium have been awarded as a new anticancer agent. But up to now, little is known about the mechanism of organogermanium compounds and organotin compounds.In this dissertation the interactions between organotin compounds (e.g., dimethyltin, trimethyltin et al) and the natural amino acids (glycine, alanine) were studied mainly by means of infrared spectroscopy, the data provided evidences for the understanding on the nature of the reaction and the binding mode of amino acids.It is therefore concluded as follows:1. Glycine can coordinate with organotin of lesser base group.2. The time and temperature can not affect the interaction of glycine and organotin.3. When glycine interact with dichloride-dimethyltin, the N of amino acid and the carboxylate O coordinate and form a molecule with five membered ring.4. When glycine interact with trimethyltin chloride , only the carboxylate O of amino acid is coordinated.5. The coordination mode of alanine and dichloride-dimethyltin is currently unclear.