A Study On The Dopamine Of Immunohistochemistry In The Marginal Division Of The Rat Striatum

Dopamine (DA) is the most abundant catecholamine neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, cognition, emotion, positive reinforcement, memory and learning, and endocrine regulation. Disorder of the dopamine system has been linked with Parkinson's disease,Tourette's syndrome,schizophrenia, hyperprolactinemia ang addiction. Dopamine plays role both in the physiology and pathology through its special receptors.Learning and memory are the most advanced functions in brain. Learning is gaining and development of experiences(behavioral habits,perception,thought);Memory is keeping and reappearance of experience.Rescently, more and more studies have been focus on the effect of dopamine and its receptors on learning and memory.The marginal division(MrD),first discovered by Shu Siyun, is a newly termed subterritory of the striatum with function related to learning and memory. It forms a belt-shaped zone locating at the caudal margin of the striatum and surrounding the globus pallidus, running dorsoventrally. Based on its location and shape, the area is termed "marginal division". It is distinguished from the rest of striatum by the neuronal shape, special connections, function, and intensely expressed immunoreactivities of many neuropeptides and neurotransmitters. Studies have shown that the marginal division is associated with memory and learning.The distribution of dopamine and tryosine hydroxylase immunoreactivity in the rat striatum marginal division was here investigated by using immunohistochemistry ABC method. The mechanism of memory and learning in the MrD performed by dopamine and its receptors was discussed.Methods and ResultsThe immunohistochemistry method was used to investigate the distribution of dopamine and tryosine hydroxylase immunoreactivity in themarginal division of rat striatum using DA and TH polyclone antibody. TheDA and TH immunoreactive fibers and terminals were distributed more densely in the MrD than that of the other part of striatum and located in the MrD.ConclusionThese results suggested that the marginal division of the striatum contain -s many dopamine fibers and terminals which imply that the DA might play an important role in the mechanism of learning and memory function of the marginal division.