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Temperature Effect On Neuron Membrane Ion Channels In A Noise Enviroment

Posted on:2006-04-21Degree:MasterType:Thesis
Country:ChinaCandidate:H HuangFull Text:PDF
GTID:2120360152995059Subject:Theoretical Physics
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We introduce the development of neuroscience in theoretical biophysics at first, then give a summary description of the model of our paper, including the basic structure of neuron, the neuron membrane ion concentration distribution, the ion potential grads and the balance potential, the resting potential ,action potential of the neuron. After that we give a presentation of ion lysenkoism which describe the potential change between the two sides of membrane and present the Hodgkin-Huxley model and it's equations set.We introduce the basic conception of stochastic resonance and coherence resonance subsequently. Base on the Hodgkin-Huxley neuron model, we describe the essential characteristic of Hodgkin-Huxley equation, such as the neu-ronal exciting threshold, phase lock, the bifurcation figure and so on. Then we add a noise to the neuron's environment, when the system doesn't exist signal or not, we compute the neuron's action potential which change with time, and analysis the stochastic resonance and coherence resonance which be likely to happen in the system.Base on the model we have introduced previously, we consider the effect of temperature to neuronal action potential. The temperature is a very important factor because it can effect the open and close probability of the ion, and effect the whole neuron. However almost no one study the temperature's effect in theory. Base on the Hodgkin-Huxley model, we add a temperature factor and compute the evolution of the neuron system by means of numerical simulation, studied the effect of temperature on neuron's statistics property. We found that: 1. Raise the temperature can make the action potential more frequently, but the action potential will vanish if the temperature is too high. 2. The rise of temper-atue can change the power spectrum density, by define a coherence factor j3, on the condition that noise intensity is a constant, when the temperature increases in a limited range, the coherence in the system become distinctness, the temperature make the coherence more strong. But if the temperature rise too high, theneuronal action potential will vanish, and coherence doesn't exist in the system.
Keywords/Search Tags:neuron, Hodgkin-Huxley equation, noise, temperature effect, coherence resonance, stochastic resonance
PDF Full Text Request
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