| Objective: When the vessels are injured, medial vascular smooth muscle cells (VSMCs) can be phenotypically changed from the contractile (differentiated) state to the synthetic (dedifferentiated) state, and can migrate into endothelium and secrete cytokines and extracellular matrix (ECM) proteins. Migration of VSMC is mainly regulated by the interaction of ECM with integrin αvβ3 on surface of cells. There is a great relationship between OPN and cell adhesion and migration in many ECM proteins. RGD-mediated interactions of OPN with αvβ3 and αvβ5 can induce many cell biological behaviors, such as proliferation, migration, adhesion and so on. Non-RGD-mediated interactions of OPN with α9β1 and α4β1 that are dependent on SWYGLR sequence regulate many cell behaviors. Previous studies indicated that peptides containing a RGD sequence and peptides with a SWYGLR sequence could block the binding of OPN to the integrins to inhibit VSMC adhesion, migration, and macrophage infiltration. Small peptides that display inhibitive roles as decoy oligopeptides may be used to prevent and cure vascular remodeling diseases such as atherosclerosis, restenosis. However, up to now, small peptides are synthesized via chemical methods and their prices are very expensive, which restricts their clinical application. So,...
|
PDF Full Text Request