Preparation Of Monoclonal Antibodies Against Glycophorin A

The red blood cell blood-group is refers to on the red blood cell membrane the special antigen type. The red blood cell blood-group research not only can guarantee the safe blood transfusion, saves the life, at the same time appraises in the medical examiner, the hereditary disease, cancer, viral and in the parasite disease research is acting the important role. To 20 century's ends, the international blood transfusion association (ISBT) has divided into the red blood cell antigen 29 bloods-group systems, 600 many kinds of antigen decisions bunch, thus causes the blood-group study research to develop into an independent discipline. Except ABO, outside the Rh blood-group system, the MN blood-group system also is a kind of important red blood cell blood-group, this system antigen by is located in the 4th chromosome the GPA gene code, mainly has M, the N two antigen epi-positions, two differences lie in: When GPA molecular N terminal 1, 5 ranks don't for serine and glycine, the performance is the M antigen, when its corresponding position for leucine and glutanic acid, the performance is the N antigen. In addition, in member other amino acids sequence homogeneous phases with. The MN blood-group system antigen immune body does not gather serious case of illness and so on blood transfusion response, newborn hematolysis and own immunity anemia which causes also when has the report, therefore, overseas already takes the MN blood-group conventional the examination project, because lacks the correlation detection immune body actually, this examination is undeveloped in the domestic each big hospital and the blood bank. This research goal lies in through prepares the human red blood cell...