Clusterization Of The MAGE Family Based On The Transcriptional Pattern And Characterization Of Its Consistence With The Functions

People are working hard to discover new Melanoma Associated Antigen (MAGE) gene and their function since the first Melanoma Associated Antigen (MAGE) member, MAGE-A1, was discovered and cloned from Melanoma cell in 1991. So far, there are more than 30 members in MAGE family, consisted of MAGE-A, B, C, D, E, F, G, H, L2, Necdin, MAGE-I, J, K subfamily (Table 1). As the gene family is complicated, it will help us to study their identical and different functions if they are well classified, and thus we can breakthrough the limitations of individual gene. In view of this, according to the conservation of regulation sequence in MAGE family among the human being, mouse and rat, we predict the cis-acting element and trans-acting factor which may regulate...