Magnetic Resonance Imaging Simulations Of Intermolecular Multiple-Quantum Coherences

Intermolecular multiple-quantum coherences (iMQC) is hot topic in nuclear magnetic resonance (NMR) community in recent years. It has a potential application in MRI. Although the signal intensity of iMQC is lower than general MRI's, it includes specific imaging parameters such as dipolar correlation distance. Therefore, iMQC imaging may provide new contrast mechanism.Combining the iMQC with dipolar field treatment, iMQC imaging signals of a three-dimensional sample was simulated systematically, by the algorithm of non-linear Bloch equation with dipolar field. Contribution of variant parameters to iMQC imaging contrast and specific imaging information were also deeply discussed. The main results are summarized as follows:Imaging signals of iMQC of one-component systems under CRAZED, modCRAZED and MultiCRAZED pulse sequences and contribution of variant parameters to iMQC imaging contrast were simulated. The simulation results agreed with theoretical analysis and experimental results. It showed that iMQC imaging has higher imaging contrasts than general MRI's. iMQC imaging offers new information and mechanism. Imaging signals of intermolecular zero-quantum, double-quantum and single -quantum coherences of two-component systems were simulated. By simulation, contribution of chemical shift to iMQC images was predicted and discussed. Contributions...