| This dissertation is consist of two parts.In the first part,we discussed the characterizations of Hypersphere in Euclidean space,summarized some theorems about the characterizations of Hypersphere,we obtained some equivalent theorems on the characterizations of Hypersphere in E3, E4, E5, E6 and given simple proof, generalized several theorems.Theorem A:Let M(?)En+1 be a compact hypersurface with an orthogonal system of lines of curvature.Suppose:①ki> 0, i = 1,2, ,n;②the boundary ?M of M consists of umbilical points;③H 1 = C1( H = C);Then M is a part of a hypersphere.Theorem B:Let M(?)En+1 be a compact hypersurface with an orthogonal system of lines of curvature.Suppose:①ki> 0, i = 1,2, ,n;②H 2 = C2( Ri jij= C′) ;Then M is a part of a hypersphere.Theorem C:Let M(?)En+1 be a compact hypersurface with an orthogonal system of lines of curvature.Suppose:①ki> 0, i = 1,2, ,n;②the boundary ?M of M consists of umbilical points;③there is,on M ,f i:M→R being positive functions such that the matrix (b kl )( n-1 )×( n-1 ) is positively semi-definite for pairwise different i , j1 , j2 , , jn-1 , , ;bkl = f jk+ f jl(?)f ik≠l2( );bkk= f i + fjkThen M is a part of a hypersphere.In the second part, the conception of Infinitesimal Isometry of Surfaces in Enis introduced, we generalized some results about Infinitesimal Isometry in E3, E4,E5 by theory of partial differential equation (solution of partial differential equations) and obtained a theorem about Infinitesimal Isometry of Surfaces in En.Theorem D:Let M: D→En, D(?)R2 a bounded domain,be a surface. n: M→N(M) is a section, formΙΙm ( nm, ?) is positively definite for m∈M, vector n m and mean curvature vector is not orthogonal at m .Let V is Infinitesimal Isometry of M , V m belong to the vector space spanned by Tm (M) and n m for m∈M.If m∈?M, V m orthogonal to Tm (M).then V =0 on M . |