An Efficient And General Method For The Preparation Of β-Enamino Ketones And Esters Catalyzed By Silica Phosphoric Acid

In organic synthesisβ-enaminones and Esters are important intermediates and have an important value in medicine, biology, catalysis and materials science, so they have been a significant focus for researchers from different countries. Now (3-enaminones and Esters have infiltrated into the organic synthetic chemistry, polymer materials, biochemistry, bio-medicine, environmental chemistry, pharmaceutical chemistry and other subjects, and led to new areas of the formation and development of organic chemistry. Therefor, we carried on the synthesis and properties of P-enaminones and esters, studied the new type of Lewis acid catalyst Silica Phosphoric Acid, and obtained a series of interesting and innovative results.In this thesis, based on the review of the applications and synthetic methods of different kinds of theβ-enaminones and esters in recent years, the new synthetic method for theβ-enaminones and esters fromβ-dicarbonyl compounds and amines have been investigated and established. A series ofβ-enaminones and esters were synthesized; using the new Lewis acid catalyst Silica Phosphoric Acid and exploring its catalytic properties, a series of significant and innovative achievements have been achieved. The main results obtained are as follows:we have developed a efficient approach for room-temperature solventless synthesis ofβ-enaminones andβ-enamino esters by condensation of different aromatic or aliphatic amines with variousβ-dicarbonyl compounds in the presence of Silica Phosphoric Acid as catalyst. Simple experimental procedure, mildness of the conversion, clear reaction profiles, excellent chemoselectivity, short reaction times, and low cost, stability and reusability of the catalyst are the noteworthy advantages of the protocol.