Synthesis And Application Of Amphiphilic Sericin-Graft-Polyisoprene Copolymers

21st century is the era of life sciences and health industry, health industry has become the world's most active industries. As time flies, the health and environmental friendly medical materials play the increasingly important role in the health industry, and it is in a state of sustainable development. The research and development of avirulent safe medical materials are very important for protecting the natural human health and promoting the development of human civilization. Countries around the world have invested a great deal of energy on research and development of green and healthy materials, and the materials are forming of new high-tech industries.Natural rubber is widely used as the production of medical gloves, examination gloves, condoms and other disposable medical supplies due to its excellent physical properties. These low cost and short lived Medical supplies did not have any substitute, and the market demand will maintain sustained growth. Widespread allergic protein in the natural latex limited the application of latex products greatly. Sericin has many properties such as antibacterial, anti-inflammatory, antioxidant, corrosion-resistant what Nature rubber need but don't possess rubber. The combination of both not only can improve the allergy problem, but also endowed Nature rubber many excellent performance what is difficult to obtain by other modification approach.An amphiphilic sericin-graft-polyisoprene (S-g-PIP) copolymer nanoparticles was synthesized by radical polymerization in this topic, NRL and S-g-PIP were mixed through heterocoagulation to form composite latex particle with a core-shell structure by the ionic bond. In core-shell structure, the shell is the graft copolymer S-g-PIP and the core is the NRL. The hydrophilic sericin/hydrophobic polyisoprene segments in S-g-PIP were efficiently entrapped on/into the potein and rubber hydrocarbon in NRL particles through hydrogen bonding and good compatibility, resulting in the formation of a certain density of cross-linked network. This enhanced the compactness, physical and mechanical properties of, the outer layer sericin gived latex products the good solvent resistance, anti-allergy and anti-bacterial. And the most important is that the analysis of cellular toxicity tests proved that modified latex film is only mildly toxic. The initial purpose of lowering the latex allergens has been received.On this basis, bio-enzyme was applied to the modified natural rubber with catalyzing crosslink of proteins, generating cross bonding in potein of S-g-PIP and NRL. The role of chemical crosslinking, hydrogen bonding, ionic bonds degenerated potein in different structural levels, resulting in the modification of allergic protein inNRL, this is also provide by the cellular toxicity tests.All this suggests that a suitable NRL modification with S-g-PIP and bio-enzyme may complement the properties of NRL (excellent elasticity, exibility and resistance against splitting) with those of sericin (antimicrobial activity, antioxidation, UV resistance, and moisturization) and, open the way to preparing barrier products of low allergenicity from renewable sources under mild reaction conditions.