Synthesis Of Novel Oxazoline Ligands And Selective Oxidation Of Alcohols

Thesis is consisted of three chapters:Chapter one: The development of single-oxazoline ligand and selective oxidation of alcohol reaction.Single oxazoline ligands research background is reviewed. We briefly introduce the types of single oxazoline ligands and the application in asymmetric reactions and the synthetic method ofβ-amino alcohol. Meanwhile, oxidation of alcohol is also summarized.Chapter two: syntheses of novel single-oxazoline type ligands2–(5–tert–butyloxazol–2–yl )–6-[(R)–4–phenyl–4, 5–dihydrooxazol– 2–yl] pyridine ligand 8 and (S)–diphenyl [6–(4-phenyl–4, 5– dihydrooxazol–2–yl] pyridine–2–yl) methanol 13 were successfully prepared.Chapter three: a novel catalyst system for selective oxidation ofalcohols to aldehydes and ketones In the presence of 2, 6–bis (5–tert–butyloxazol–2–yl) pyridine, pyridine-2, 6-dicarboxylic acid and FeCl3·6H2O, secondary and benzylic alcohols are oxidized to the corresponding ketones and aldehydes by using hydrogen peroxide as oxidant. This method is high yielding, environmental and operationally simple.