The Modification Of Resin And Adsorption Properties Of Oral Adsorbents For Creatinine

Creatinine is one of the major toxins in patients suffering from chronic renal failure(CRF). The oral adsorbent can be used in the gastrointestinal tract to remove creatinine for delaying disease progress. In this paper, resins were be modified and their adsorption properties of creatinine were studied.The single coagulation method by aqueous phase separation was used to coat the resins with the chitosan. The effects of the concentration of chitosan solution, the mixing time, the pH and the concentration of glutaraldehyde solution were investigated in terms of adsorption effect of creatinine. The adsorption isotherm and the adsorption kinetics using the first-order and the second-order kinetic models were studied to evaluate the adsorption effect of creatinine on modified resins. The morphology and structure of the modified resins had been characterized by IR and TEM, they showed that the resinss be modified successfully. The results showed that the H103 resin coated by the mass fraction of 0.02% chitosan solution adsorbed the highest amount of creatinine. And the adsorption of creatinine reached equilibrium within 6h; the adsorption capacity reached 2.72mg/g. The adsorption processes fited the Langmuir adsorption isotherm and the adsorption curves conformed to the second-order rate formula.The single coagulation method by aqueous phase separation was used to coat the resins with the gelatin which is a natural material. The effects of the ratio of raw materials and the concentration of gelatin solution on the adsorption effects of creatine were investigated. The morphology and structure of the modified resins had been characterized by IR and TEM, they showed that the resins were well coated and modified. The adsorption isotherm and adsorption kinetic curves were used to describe their adsorption capacity. It was found that the adsorption of creatinine reached equilibrium within 7h and the adsorption isotherm curves conform to the the Langmuir equation. The adsorption processes conform to the second-order rate formula. The modified H103 resin has the highest adsorption capacity of creatinine which is 3.43mg/g.The adsorption capacities of ADS-4 resins, the H103 resins coated by chitosan and gelatin separately, and medical charcoal capsules were investigated under the same conditions. It was found that adsorption capacity of the modified H103 resin by gelatin was better than chitosan modified H103 resin and ADS-4 resin. But gelatin modified H103 resin has smaller adsorption capacities than the medical charcoal capsules.