The Syntheses Of Ranolazine And Its Analog And Their Activities Reach In Anti-angina

The incidence of angina pectoris tends to highten these years, along with the increase of the social pressure. At present, There are several main types medicines for angina pectoris, namely, nitric acid ester> calcium antagonist -blocking agent and so on. They have their respective advantages and disadvantages. And The workers of medicine are always trying their best to find more efficient medicine in these field.Ranolazine, a kind of anti-angina medicine not only can affect calcium entry but also P -blockade, in the preclinical research, it manifests distinguish curative effects, and few side-effects. It also can compensate the defects of some other medicines for angina. So it is necessary to find a new feasible process of synthesizing Ranolazine.At the same time, according with the rules of dissection and association ,we design and synthesize five compounds which are not reported in the document, using Ranolazine as lead compound. Their structure have been identified by MS IR 'H-NMR and Elemental analysis. In addition, the pharmacological experiment has shown that their anti-angina curative effects are distinguished. Among them, TM4 should be the best one, which excels the contrast medicine-propranolol.