Synthesis And Application Of A New C₂-symmetric Chiral Bisaminoalcohol Catalyst In Diethylzinc Addition Reaction

1) The C2-symmetric chiral bisaminoalcohol catalyst (l-{2-[2-(Hydroxy-diphenyl-methyl)-pyrrolidin-1 -ylmethyl] -benzyl} -pyrrolidin-2-yl)-diphenylmethanol was prepared and applied to asymmetric addition of diethylzinc to aldehydes. Chiral secondary alcohols were produced in high yields with moderate e.e.2) The chiral pharmic intermediate (l,3S)-diamino-4-phenyl-(2#)-butanol was prepared with good yield. The use of solid alkali in this kind of reaction has not been reported yet.3) The ring-opening reaction of potassium (ft)-(+)-2,3-epoxy-propanoate was achieved by reaction with Grignard agent to obtain optically pure chiral a-hydroxy acid.