The Study Of The Encapsulation And The Sustained-release Properties Of Acetaminophen

Acetaminophen is an extensively used medicine which can be used to treat cold, headache, fever etc. However, it has some side-effects and low utilization ratio.In this paper, we adopted some different wall materials which is biocompatible and biodegradable, with no side-effect or toxicity to human body.After having tried different methods and conditions, we found the best conditions for the microencapsulation of the acetaminophen. At the same time, we studied the related sustained-release properties of the microcapsules prepared.1. The nm-level PMMA microcapsules of acetaminophen were prepared by in-situ polymerization method with EtOH as the dispersing agent for core material, MMA as the wall material, and the hexane as the intermedium.2. The sodium alginate microcapsules of acetaminophen were prepared by integration of emulsion and double-coagulation methods. The microcapsules has smaller particle diameter and was ruleless and multinuclear.3. According to the property that acetaminophen has stabilized UV absorption, we measurated the volume of acetaminophen in the microcapsules by UV spectrophotometer, and found the medicine bearing capacity in the both microcapsules was high.4. We also studied the sustained-release properties of the microcapsules which were prepared from the above systems by UV spectrophotometer. And the study showed that: we can control the sustained-release behavior of the microcapsules with the adjust of the preparation conditions such as: adopting different wall materials, adjusting the core/wall ratio, changing the particle diameter etc.5. In conclusion, our study showed that the medicine microcapsules made from acetaminophen has smaller particle diameter, higher medicine bearing capacity, higher encapsulation ratio and the adjustable sustained-release property...