Studies On Biologically Active Heteroatomic Organic Compounds (Ⅳ)

Phosphosulfonate compounds have been found very useful intermediates which have a lot of utility and also a kind of new selective herbicides. In order to research the effect of the substituted groups of a -carbon to the biological activities of the compounds ,nine unreported a - substituted phenylsulfonyloxo-phosphosulfonate I in one series were synthesized by the condensation reaction of substituted phenylsulfonyl chloride with a -hydroxyphosphonate.Imidazolones have been found to show fungicidal,herbicidal,pesticidal and medicinal activities and have the applied foreground extensively. In this paper,we synthesized 14 unreported 2-thio-4-imidazolidineones II form aza-Wittig reaction having the advantages of easily accessible starting material and mild condition and then synthesized 48 unreported 2-alkylthio-3-alkyl(substituted alkyl)-5-furylmethylideneimidazolones III by the S-alkylate of compounds II.The biological activities of I were studied and found that they showed herbicidal activities.The effect of the substituted groups with big volume of a -carbon to the biological activities of the compounds was studied.Herbicidal activity of 5-hetercyclomethylidene imidazolones III was found firstly and partial compounds exhibited high inhibition of Rape and Barnyardgrass.The fungicidal activity of compounds II and compounds III was studied.The results showed that the fungicidal activity of compounds III was better than that of compounds II .partial compounds III exhibited high inhibition of partial Bacteria.Seventy-one compounds in three series were all identified by MS and IR spectroscopes and most of them were identified by 'H NMR spectroscopes.