The Study On The Novel Process For Preparation Of M-Alkxyl Thiophenol Compounds

Based on the analysis of bibliographer and evaluation of the principles of different processes, the novel process for synthesis of m-alkoxyl thiophenlo compounds, especially m-methoxy thiopHenol, a new pharmaceutical intermediate was studied in this paper. The pharmaceutical intermediate, m-methoxy thiophenol, was prepared by diazotization, esterification, hydrolyzation of 3 -methoxy aniline which was synthesized by the reaction of 1,3-dinitrobenzene and sodium methoxide. 3-methoxyaniline and m-methoxy thiopHenol was isolated and purified through the methods of distillation, oxidation and reducing respectively. The chemical structures of the intermediate and the product were identified and confirmed by IR, NMR, MS. Furthermore the method of analysis was studied and the purity of the product was determined by GC.The novel process was evaluated. The process parameters were selected by optimium experimental or Pilot Tests. The industrial process was designed and the new process for preparation of m-methoxy thiopHenol was brought about industrialization. The yield of the m-methoxy thiopHenolwas 35.7% and the yields of the main reactions such as substantative, reducing and diazotization were 68.3%, 99%, 52.4% respectively. The novel process is characteristic of simplicity, low cost and practicable in industry.It provides the theoretical basis and the feasible process parameters for the industrialization of m-alkoxyl thiopHenlo compounds.