The Novel Methods For The Synthesis Of Organic Selenides In The Presence Of Organometalics And The Synthesis Of Blocks For Assemblying To New Molecular Shuttles

Organic selenides have attracted more and more attentions of chemists, pharmacologists and biologists for their important role in the organic synthetic transformation and their latent biological activities. It is a hot topic in the field of their new synthetic methods and the research of their bioactivities. But there are some disadvantages in the synthetic methods of organic selenides, such as needing stern conditions for reaction, using poisonous materials and processing complicated multi-step process. We put forward a novel method for synthesizing the allyl selenides by cheaper and innoxious zinc reagents. Such method can afford high yields and has simple operations. Alkynyl selenides are a species of important intermediates in organic synthetic transformations, currently their synthetic methods need no-water and no-oxygen operations and their yields are much lower. Considering the highest basicity of cesium hydroxide, we plan to use terminal alkynes react with diaryl diselenides to afford alkynl selenides. This method has the advantages of simple operation and without worrying about the presence of water and oxygen.Molecular shuttle is the basic compound for constructing molecular machine The research in this field is in a front field of science. We firstly put forward the torpid molecular shuttle and the inner salt molecular shuttle duo to the structural character of protein and lecithin, and we have designed two species of these molecular shuttles. The blocks for constructing to these shuttles were synthesized. The infections of synthetic methods and conditions on the multi-step process are discussed. Intermediates and objective molecular synthesized are characterized by 1H NMR,13C NMR and 31P NMR, and the relationships of molecular structure and spectral data are analyzed.