Pressure Sensitive Adhesives And Technology Used In Transdermal Drug Delivery System

This thesis mainly developed and studied the characters of the hydrophilicnon-ionic polyurethane pressure sensitive adhesives(PSAs) and a series of hybridhydrophilic PSAs. The transdermal drug release properties of drug loaded methoxypoly(ethylene glycol)-b-poly(D,L-lactic acid) nanomicelles (PMT) were alsoinvestigated, by which a way to make macromolecular drug to penetrate the skineasily maybe was found. The hydrophilic non-ionic polyurethane PSAs were synthesized by polyadditionof polyether glycol, diisocyanate and extender. Polyethylene glycol(PEG), which wasintroduced on the polyurethane chain, can offer good hydrophilicity. The effects, suchas the kinds and the molecular weight of the polyether glycols, the diisocyanates , theextenders, the temperature, the reaction time and the ratios of the materials on theproductions were also studied carefully in this work. By physical mixing and chemical cross-linking methods, three types of hybridhydrophilic PSAs, respectively polyvinyl pyrrolidone/polyethylene glycol (PVP/PEG),PVP/polycaprolactone glycol and PVP/polyvinyl alcohol hybrid systems, wereprepared by using the hydrophilic polymers. The optimal composites were obtainedby exploring a quantity of ratios of the materials and the preparing conditions. Thestudying indicate that the hydrophilic PSAs prepared in this thesis all show goodmechanical properties, compatibility with skin and drug controlled release capabilities,which suit for the TDDs. The transdermal drug delivery behavior of PMT was also studies. The resultsshow that PMT can carry the drug to go through the animal skin entirely. Thedrug-loading amount and the viscosity of the release system have great influence uponthe transdermal delivery. The methoxy poly(ethylene glycol)-b-poly(D,L- lactic acid)nanomicelles have application foreground in TDDs.