Study On The Synthesis And Bioactivity Of Methyl-s-triazine And Urea Derivatives

Heterocyclic compounds as medicines and pesticides have been developed most quickly and have become the new trend in the development. In the new developed medicines and pesticides heterocyclic compounds are the most important domain. Ureas show biological activities of theγ-Secretase inhibitors and ALS/AHAS inhibitors, and weed photosynthesis inhibitors.2,4,6-Trichloro-1,3,5-triazine is the one kind of the most important intermediate in the fields of the organic synthesize and which play essential roles in some biosynthetic and metabolic pathways. In this thesis, the method for preparation of bioactivity compounds ureas from 2,4,6-trichloro-1,3,5-triazine has been studied and their bioactivity has also been tested.Methyl halides are reacted with magnesium catalyzed by crystalline iodine, which afford methylmagnesium halides. Methylmagnesium halides perform Grignard reaction with 2,4,6-trichloro-1,3,5-triazine, which gain 2,4-dichloro-6-methyl-1,3,5--triazine. Methods for preparation of 2,4-dimethoxy-6-methyl-1,3,5-triazine and 2-methoxy-4-methylamine-6-methyl-1,3,5-triazine have been studied. Their yields are about 60-95%. The structures of these productions have been confirmed by elemental analyst, IR, 1H-NMR which showed that the structures of these compounds are the same as desired.Phosgenation of aryalamines or sulfonylamines produce corresponding isocyanates, which are condensed with 2-methoxy-4-methylamine-6-methyl-1,3,5-tri--azine, which afford corresponding ureas. Their yields are about 80%. The structures of these productions have been confirmed by elemental analyst, IR, 1H-NMR which showed that the structures of these compounds are the same as desired.The bioactivities of ureas in this thesis are being tested.