Preparation Of New Chiral Capillary Column And Study Of Its Chromatographic Performance

In this thesis, a new type of column was prepared by coating cyclodextrin derivatives mixed with normal stationary phase (ov-7) on capillaries, the main work was described as follows: β-cyclodextrin derivatives of perheptylated-β-CD and 2,6-O-diheptyl-3-O-trifluoroacetylated-β-CD were synthsized as chiral stationary phases for capillary gas chromatography.Being dissolved in ov-7,it was found that these cycloidextrin derivatives had good film forming properties, and 2,6-O-diheptyl-3-O-trifluroacetylated-β-CD was moderate polar stationary phase ,while perheptylated- β -CD was low polar stationary phase. With the wall had been modified by BaCO3 prior to coating,the capillary column were coated by superdynamic method,they had good thermal stability and fine separation abilities .Enantiomeric seperation was performed on chiral capillary column,the results showed that 2,6-O-diheptyl-3-O-trifluoroacetylated-B-CD has higher enantioselectivity than perheptylated-B-CD for chiral alcohols,amines.The results also indicate that many factors,including cyclodextrins cavity ,substituted groups,the polarity,the size and interactions,played an important roles in the seperation of positional isomers and chiral substances.