Studies On The Synthesis And Biological Activities Of New Pyrazolopyrimidine Derivatives

In recent years, many pyrazolopyrimidine derivatives have possessing a wide spectrum of biological activities, which can be used in medicine and pesticide fields. Pyrazolopyrimidine skeleton, which has 2, 3, 5, 6, 7 positions, can be changed different substitute to change its bioactivities. In order to find highly biological activities compounds, 5 series, 35 new pyrazoleo[l,5-a]pyrimidine derivatives were synthesized. The biological activities of these compounds were examined and the results showed that some of them had fungicidal, herbicidal or plant-growth regulating activities.Aminopyrazole and enaminone are two important and versatile building blocks for the synthesis of a number of heterocyclic compounds, especially for the synthesis of pyrazolo[l,5-a]pyrimidine derivatives. In this paper, we synthesized the title compounds (1-5) based on the ring closure of 5-amino-1H-pyrazoles with enaminones.More recently, microwave irradiation has broken new grounds in synthetic organic chemistry, not only in terms of the reduction of reaction time, but also simplicity of reaction procedures. The combination of microwave irradiation with inorganic solid support further extends the application scope of microwave, thus forming a promising candidate for eco-friendly...