Design, Synthesis And Molecular Recognition Of Disulfide Bond-bearing Cyclopeptides

Cyclopeptide with special architecture and useful functions in chemistry and pharmaceutical chemistry is a new challenging field that is quickly developing. In this dissertation, cyclopeptides bearing disulfide bond have been designed, synthesized and their molecular recognition for D,L-amino acid methyl esters have been studied. A series of useful and creative results have been obtained.Novel disulfide bond-bearing cyclopeptides have been designed and synthesized by iodine oxidation of bis (S-Acm) of Glutamic acid and Aspartic acid linear peptides derivatives. With this synthetic method we have successfully synthesized a series of disulfide-bearing cyclotripepetides and cyclopentapepetides. Their structures were identified by MS and 1HNMR.Moreover, cyclopentapeptides as hosts have been used to the recognition of D,L-amino acid methyl esters and we have got some good results especially on enantiselective recognition of D,L-amino acid methyl esters hydrochloride.