| Pyridine and chloro-pyridines are very useful chemical materials,chemical intermediate, medical and pesticide intermediates. In recent years, it has been a hotspot in chemical field that chloro-pyridines are produced directly from pyridine, especially the poly-chloro-pyridine. So, it has been considered as a hard question world widely.In this paper, according to a great deal of references, the system of pyridine-chlorination was built. Several catalyst carrier and active component were tested. The optimal technologic conditions were found, which reached in a better result. A foundation was built for industrialization latter.According to the practical instance, the warm-up areas of nitrogen, chlorine, and pyridine warm-uppers were calculated. Three spiral-piping warm-uppers warmed by sand and upright fixed bed reactor for pyridine chlorination were designed and machined. They worked naturally after debugged.The result showed the catalyst (20%CoCl280%LaCl3) was a high active one for pyridine chlorination. About this catalyst the optimum react conditions are the ratio of material: nCl2:nPyridine = 8:1, the fitting react temperature: 330～340℃, the optimal flux of pyridine: 280ml/h or so.Under this condition, the conversation of pyridine reached over 90%, the yield of pentachloropyridine reached about 80%(95% pure). The catalyst has good activity and selectivity after continuous working naturally. A notional industrial design of pentachloropyridine with annual production 1000 tons was built. After economical calculation, the cost of pentachloropyridine (except fixed capital and energy sources) is far below the price on the market. It proved that this reaction system is reasonably designed and feasible economically and could be used for the magnified test and industrialization.
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