Research On Clean Process Of Carbamazepine Manufacture

Central nervous system medicine is one of the fastest developing flieds in the medical industry. Carbamazepine, as a kind of the central nervous system medicines, came into the market in 1962, and its treating scope becomes bigger and bigger. Its use on the clinic becomes broader and broader.This monograph drafted out a new process of Carbamazepine, which confirms to the requirement of cleanness manufacture. This process used the bromination and was on the basis of the old process of the Zhejiang Jiuzhou Medicine Limitied Company. In the new process, Carbamazepine is a synthesis product from Iminodibenzyl The synthetic route for the production of Carbamazepine includes the following three steps: Acyl-chlorination reaction (with bis (trichloromethyl) carbonate ), Bromization and dehydrogenation reaction and Ammonization. Only two organic solvents have been adopted in the process of manufacture, and each conditions of reaction have been optimized. The emphases of text is the study of Bromization, the enhance of the translation ratio, and the decrease of impurity. The ratio calculated by means of the quantity of Iminodibenzyl is 78%, which goes beyond 1~2% than the old process. The new process can decontaminate 1500 mt of methanol and 350 mt of toluene. The process have brought the remarkable economy benefit and community benefit. Meanwhile, all sorts of chemical cell operation in the new type airproof containers have been studied, which made sure that the least quantity of all kind of exhaust gas's pollution.This improved process carried out the cleanness manufacture of the Carbamazepine. It has important and practical meanings for industry production.