Study Of The Bromination And Esterification Of 5-(4-HydroxyPhenyl) Hydantoin And Analysis Of Products

In the paper, synthesis, classification and application of the present bactericide about hydantoins were introduced. They will have good prospect and great potentialities of market.The synthesis process of bromination and esterification of5 (4-hydroxyphenyl) hydantoin were designed. 3-bromo-5(3-bromo-4-hydroxy) phenyl hydantoin and 2- bromo-4(3-bromohydantoin) phenyl 2-methacrylate were prepared andanalyzed.1) synthesis and analysis of 3-bromo-5 (3 -bromo-4-hydroxy ) phenyl hydantoin3-bromo-5 (3-bromo-4-hydroxy) phenyl hydantoin wasprepared by 5 ( 4-hydroxyphenyl) hydantoin as material in the presence of methanol as solvent. On the investigating the effects of solvent, the ratio of raw material, reaction temperature, reaction time and catalyst on the yield, the optimum reaction conditions were obtained by using orthogonal experimental design. The yield of 3-bromo-5 (3-bromo-4-hydroxy) phenyl hydantoin was to 99.7%.3-bromo-5 (3-bromo-4-hydroxy) phenyl hydantoin was analyzed by IR Spectrum , 'H-NMR Spectrum, Element analysis and HPLC to assure its structure. Its purity was to 90.02%. its melting point, formula weight, molecular structure and solubility were given.2) Synthesis and analysis of 2- bromo-4 (3-bromohydantoin) phenyl 2-methacrylate2- bromo-4 (3- bromohydantoin) phenyl 2-methacrylate was prepared by 3-bromo-5 (3-bromo-4-hydroxy) phenyl hydantoin as material in the presence of N,N-dimethyl formamide as solvent. On the investigating the effects of solvent, reaction temperature, reaction time and catalyst andamount of catalyst on the yield, the optimum reaction conditions were obtained by using orthogonal experimental design. The yield of 2- bromo-4 (3- bromohydantoin) phenyl 2-methacrylate was to 86.8%.2- bromo-4(3-bromohydantoin) phenyl 2-methacrylate was analyzed by IR Spectrum , 'H-NMR Spectrum, Element analysis and HPLC to assure its structure. Its purity was to 65.16%. Its melting point, formula weight, molecular structure and solubility were given.Disinfect experiments about 2- bromo-4(3-bromohydantoin) phenyl 2-methacrylate and 3-bromo-5 (3-bromo-4-hydroxy) phenyl hydantoin were studied. The bactericides have appeared the bactericidal performance.