The Synthesis And Application Of Complex Of Chitosan And Derivatives Of Chitosan

Chitosan, a polymer derived from the abundant natural polymer chitin, is composed of 2-amino-2-deoxy-D-glucoseand units and 2-acetoamido-2-deoxy-D-glucose units. In recent year, chitosan has been paid great attention as biological active substance and a useful chelating agent. Chitosan and its derivatives have been used in a wide variety of fields, such as pharmaceutical carriers, immobilization agent of enzyme, adsorbent as well as separation and concentration of metal ions.This thesis has studied the synthesis of two complexes and two derivatives of chitosan linked β-cyclodextrin by different methods. The compounds is complex of silver( I) and that of copper( II). The composition and structure of the complex compounds were confirmed by UV-vis spectra, IR spectra, element analysis and ¹H NMR. The adsorption kinetics of chitosan for silver( I) and copper( II) have also been investigated. The adsorption ability of two kind of insoluble chitosan derivatives grafted p-cyclodextrin (CTS- β -CD) for p-nitrophenol and iodine is studied. This thesis includes five chapters:Chapter I: Review of the development and application of chitosan metal ions complexes and its derivativesA study on chitosan-metal ions complexes and chitosan derivatives was reviewed with 102 references in recent ten years.Chapter II: Synthesis and adsorption kinetics of silver( I ) complex with chitosanThe isothermal adsorption kinetics of chitosan(CTS) for Silver( I) ion has been investigated. The optimum adsorption condition was selected and the complex compound was prepared. The structure and the composition of the complex compound were confirmed by IR spectra, UV-vis spectra, element analysis and ¹H NMR. The result showed it is Ag(CTS)₂NO₃. The adsorption kinetics was satisfiedwith Freundich adsorption equation and first-order equation. The constant of the first-order reaction is 0.0410 h"1 at 30°C. Its apparent activation energy is 21.92 kJ-mor1.Chapter III: Synthesis and adsorption kinetics of complex chitosan with copper ionsThe isothermal adsorption kinetics of chitosan(CTS) for copper( II) ion was studied. The adsorption condition was optimized and a kind of complex compound was synthesized. The composition of the complex and structure of the complex compound were analyzed by IR spectra, elemental analysis and JH NMR. The adsorption kinetics obeys first-order equation. The constant of the first-order reaction is 0.0685 h"1 at 25°C. Its apparent activation energy is 5.60 kJ-mol"1Chapter IV: Synthesis of chitosan linked P -cyclodextrin and its adsorption Capacity for p-NitrophenolA kind of insoluble chitosan linked p-cyclodextrin (CTS- P -CD) is prepared through the formation of schiff base in which amino group reacts with aldehyde group. The adsorption capacity of it for p-nitrophenol was investigated. The result showed that the derivative of chitosan with p-cyclodextrin has property to form host-guest complexes with the model compound. The adsorption condition was optimized. The isothermal sorption kinetics of CTS- P -CD for p-nitrophenol has been studied by spectrophotometry. The result is satisfied with the Langmuir equation. In pH11.2 media, at 35°C, when p-nitrophenol initial concentration is ISOmg-L"1, the adsorption capacity of CTS- 0 -CD for p-nitrophenol is 83.76 mg-g'1, 54.56mg-g'1 higher than that of unmodified chitosan, which is only 29.20 mg-g'1.Chapter V: Synthesis of chitosan grafted P -cyclodextrin under ultrasonic assistance and its adsorption property for iodineUltrasonic method was used to assist the preparation the derivative of chitosan grafted P -cyclodextrin. The maximum amount of ï¿¡ -cyclodextrin was introduced into chitosan, which is 49.12 umol-g"1 higher than the value of 25 j^mol-g'1 reported in reference. The adsorption of chitosan with P -cyclodextrin for iodine was also studied. Theresult showed that the adsorption ability to iodine is very good. At 25 "C, when initial concentration of iodine is 12.75 mg-mL"1, the adsorption capacity is 598.3 mg-g'1 after three days reaction.