Synthesis And Biological Activities Of Novel Multi-activity Centered Nitrogen Heterocyclic Compounds

Multi-activity centered nitrogen heterocyclic compounds have good activities in pesticide and medicine fields. They have been researched as hot-topic area for a long time. In order to find novel multi-activity centered nitrogen heterocyclic pesticides and realize the accumulation of activities, enlargement of herbicide and fungicide spectra, enhancement of plant growth regulation activity, 21 new multi-activity centered nitrogen heterocyclic compounds were synthesized. Their structures have been confirmed and preliminary biological activities have been tested.Part one: 2-Chloronicotinyl chloride reacted with potassium thiocyanate to get2-chloronicotinyl iso-thiocyanate, then reacted with substituted_______pyrimidinamine underthe alkali condition to give 7 new 4/7-pyrido[3,2-e][1,3]thiazine-4-ones directly, these compounds were reported first time. The structures of the compounds were confirmed by IR, 1H NMR and elemental analysis. A possible mechanism of the reactions was proposed. The plant growth regulation activity was tested. The relationship between the structure and biological activities of the compounds were discussed.Part two: Pyridinecarbonyl chloride reacted with potassium thiocyanate leads to iso-thiocyante, then reacted with substituted pyrimidinamine to get 14 new thiourea compounds. The structures of these compounds have been confirmed by IR,1H NMR and elemental analysis. The plant growth regulation activity of the compounds were tested. The results show that most of them exhibited good biological activities. The relationship between the structure and the biological activities of the compounds were discussed.