Studies On Character Of Supramolecular Chemistry Of β-Cyclodextrin With Some Ferrocene Derivatives

Supramolecular chemistry , the emerging and up-to-date cross subject, involves all subjects of chemistry , biochemistry and material science etc. In view of supramolecular chemistry could offer an effective method for chemists to solve the long-term puzzle of improving selectivity , which has gotten a great development from the theory being put forward , especially , in chromatogram and optical analysis. Cyclodextrin(CD) , one of the most important host of supramolecular chemistry, can be used to improve all qualities of guests.In this thesis, β-cyclodextrin was used as the host . Taking advantage of its large intramolecular cavity with cylindrical shape, and the character of selectively forming inclusion complexes with some organic or inorganic molecules , β-cyclodextrin included some ferrocene derivatives in this series studies. Thus these ferrocene derivatives'water-solubility,stability,and bioavailability were all effectively improved .Firstly, Acetylferrocene-Thiosemicarbazon (TAF) , Acetylferrocene-Semicarbazone (SAF) and Benzoylferrocene-Thiosemicarbazone (TBF) were gotten through novel solid state synthensis. And then their inclusion complexes with β -cyclodextrin were respectively prepared in kneading method and microwave method. Characterizations of these inclusion complexes were systematically studied by UV,FTIR and X-ray diffractometry. Elemental analysis and the solubility determination proved that TAF and SAF all formed 1 : 1 inclusion complexes with β -CD. In room temperature, their association constants were 2.27 × 10²L/mol (TAF) and 7.82×10²L/mol (SAF),which can be explained that the combination of TAF- β -CD goes beyond SAF- β -CD.Owing to having the rich-electron radical, benzene and ferrocenyl, continuous variation plot proved that TBF and β-CD formed 2 : 3 inclusion complex. In room temperature, its association constant K= 5.04 × 10¹³L⁴/mol⁴. Furthermore, the influence of different solvents and PH on UV spectrum of TAF,SAF,TBF and their inclusion complexes were discussed respectively. The results show that different micro-environment has apparently different effects on electric spectra of guests and inclusion complexes. The research will lay the essential theoretical groundwork for further deep study.