Research On Combinatorial Bimetallic Catalysis Of Suzuki Coupling

Suzuki coupling reaction is one of the most important methodology for construction ofcarbon-carbon bond. The product of Suzuki coupling was widely used as precursors forpharmaceuticals, polymers, materials, liquid crystals, and ligands. In recent years, the report ofvarious highly efficient catalyst systems for Suzuki coupling provided more spacious prospect forits development and application. Owing to increasing environmental concerns, simplifying thehandling works and to recycling the noble metals, the heterogeneous catalyst andpolymer-bounded catalyst such as aqueous catalyst systems are presently undergoing veryrapidly.In this paper, the activity of polymer-supported palladium was improved by introducing thesecond transition metal salt in situ for catalytic Suzuki coupling, and the effect of varioustransition metals salts and bases were investigated by High-throughput experiment (HTE) method.As a result, we developed a ligand-free, simple, readily available and highly effectivePd/PVP+Ni bimetallic catalyst system for Suzuki coupling reaction. The protocol is applicable tomany representative aryl bromide substrates bearing different functional groups with good yields.Moreover, in aqueous media, the Suzuki coupling reaction can effectively be carried out with thiscatalyst system. The mechanism of the bimetallic catalytic reaction was discussed.