Inorganic Salts And Carbon Dioxide-Promoted Allylation Reactions Of Carbonyl Compounds In Aqueous Media

This dissertation studied allylation reactions of carbonyl compounds promoted by inorganic salts or carbon dioxide in aqueous media. The Barbier-Type reaction is one of the most important methods for the construction of carbon-carbon bond in organic synthesis. The advantages of the aqueous Barbier-Type reaction include that (1) it is an improved green chemistry; (2) no any protection was required for the active hydrogen of the substrates; (3) the hydrolyzation process was finished after the addition of carbonyl compounds with allyl bromide in one-pot, which reduced the experiment operations.1. Inorganic salts were found to promote the allylation reaction of carbonyl compounds with allyl bromide. Various inorganic acid, such as ammonium chloride, copper (â…¡) sulfate, aluminum sulfate, mercury(â…¡) chloride, cerium(â…¢) sulfate and cerium(â…¢) chloride, have been evaluated for copper powder, zinc powder, or tin powder-mediated allylation reactions of carbonyl compounds with allyl bromide in aqueous medium. The results showed that tin powder was the most effective than did both copper powder and zinc powder. The results also...