Synthesis Of Model Compounds Of Superoxide Dismutase And Their Chemical Simulation

Superoxide radical anon O~2-is an active species generated during biological oxidation utilizing molecular oxygen. It is involved in several important biological processes. High level of O2- may cause cell damage leading to the appearance of several diseases. It was reported that in human body O2 - is related to the occurrence of such abnormities as aging,cancer,diabetes,mental disorder and arthritis.Superoxide dismutase (SOD)is a metal enzme found in animals,plants and microorganisms.SOD catalyzes the conversion of superoxide radical anion to hydrogen peroxide and oxygen, thus reducing its body content. Commercial SOD products come from animal blood extracts and are expensive due to the high cost related to tedious extraction and preparation. In addition I,its lifetime in human body is onl a few hours. Its widespread application is further limited by its poor cell permeability due to the large size of SOD.Therefore, chemical synthesis of SOD mimics has attracted the attention of many chemists. SOD mimics hold great potential as pharmaceutical agents for the treatment of many diseases.We have been involved in the synthesis and metal coordination chemistry of porphyrins and calixfiirans.These molecules are screened as potential model compounds of SOD. Furanomacrocycles and porphyrin are characterized by a hydrophilic cavity in their centers in which metal cations and certain neutral organic compounds are selectively bound depending on their ionic diameter and have the function of crown ethers which comples with special metal cations and certain neutral organic compounds.These macrocycles Those compounds containing the furan ring are expected to have a different "Molecular Recognition"runction. So Furanomacrocycles have become important targets of synthetic organic chemists de to their potential application in many areas such as molecular recognition, molecular self -assembly and supermolecular catalysis.This research project is focused on the improved and new synthesis of...