A Probable Diabetes Mellitus Drug--Synthesis And Properties Of Vanadyl L-threonate Complex ResearchesonthePreparationofChrometanMetallomicellarCatalysis:HydrolyticKineticsofp-NitrophenylPicolinateCatalyzedbyCopper(Ⅱ)OximatoComplexesinMicellarSolutio

In this paper, the source of diabetes mellitus was introduced, and in light of the analogy in chemical and biological behavior between non-essential ions and essential ions, the chemical species of vanadium compounds under physiological condition and their physical-chemical characters, which are important for the biological effects are reviewed. The mechanisms of hypoglycemic activity of insulin-mimic vanadium compounds and development of anti-diabetes drugs are also introduced. The dark blue powder of vanadyl L-threonate was obtained by extracting with alcohol in the concentrated solution derived from the reaction between Calcium L-threonate solution with vanadyl oxalate solution at 60℃and 4 hour. The composition of the new compound was determined by ICP and elemental analyses and its formula fits [VO(C4H6O5)]2?3H2O. The IR spectra indicated that VO2+ in the compound coordinates to oxygen atom of the carboxyl group pentaring and oxygen atom of hydroxy group of ethanol attached to carboxyl group forming,while the proton of the carboxyl group is dissociated. The results of TG-DTG show that the compound has fairish stability and that the intermediate and final product of the thermal decomposition of the compound are VO(C4H6O5) and V2O5. We research the new complex of vanadyl with L-threonate, in order to obtain an ideal anti-diabetes mellitus drug. This paper intuoduced a new method of preparing Chrometan. We tried to find a kind of reducer, cheap in price, stable in property, urea to prepare chrometan. We Learned that the reaction temperature, quantity of reducer, acid degree are main factor of the reaction. Through a lot of experiments, we couldn't get valuale and feasible conditions of this reaction. Recently,employing micelle, especially metallomicelle made of metal complex and micelle as model systems for artificial hydrolytic enzyme has become intriguing research area. Two copper(II) oximato complexes were used. And the hydrolysis of carboxyl acid ester PNPP , catalyzed by these two complexes was investigated in different micellar systems. The ternary complex kinetic model for metallomicellar catalysis has been proposed in this paper. The results obtainted indicated that these two complexes bearing oxime groups exhibit highly catalytic activity on the hydrolysis of PNPP. It also suggested that both of the hydrolytic cleavage of PNPP in cationic CTAB micellar solution more effectively than that in nonionic Brij35 micellar solution, which may be due to the difference in the constituent and the structure of the complexes and electrostatic interaction between micelle and complexes or substrate.This paper may provide theoretical view and significative clue for elucidating the hydrolytic mechanism of enzymes and for designing highly efficient artificial enzyme model systems.