Study On Modifying By Oxidation And Graftting With Antitumour Medicines On Carbon Black Surface

In this paper, oxidizing the nano carbon black by nitric acid was investigated. At the same time, graftting hydroxyl on carbon black surface with benzoperoxide (BPO) as the initiator was studied, too. The results showed that a large number of oxygen groups, for instance carboxyl, hydroxyl and phenol hydroxyl etc. were transplanted on the carbon black surface undergone long time at the high concentration of nitric acid and high-temperature. The dispersive ness of the nano carbon black modified by oxidation was improved remarkably in water. And, the results of its pharmacology test on the mice showed that nano carbon black oxidized can enter the first, second and third level of the lymphs within one minute. So it is good track ability as lymph dying and showing, and hopeful to become a new generation dying and track pharmaceutical in tumour treating. Previous research proved that carbon black, as the dying and track pharmaceuti-cal, don't lend to the influence of sudden change, reproduction toxicity or the canceration, after injecting to the human body. And, nano carbon black is possessed of peculiar target ability by reason of its size belonging to the range of colloid, so it can be engulfed by the macrophage cell, and reach canceration position not by blood vessel but by lymphatic vessel directly. Therefore, it was studied that the nano carbon blacks oxidized were used for carrier of target to graft two antitumour medicines, 5-Fluorouracil (5-Fu) and Oxaliplatin (L-OHP). The synthetical method could be used to other antitumour medicines with amine groups or hydroxyl groups to the carbon black, especially the medicine working in the lymph position. The dispersive stability of carbon black oxidized in water is good, which was proved by experiments in 10 days with light or 6 month with 40 degree Centigrade. Besides, the ability of absorbing antitumour medicine was investigated. The results indicated that carbon black oxidized can absorb strongly medicine with a large amount of active group such as amine and hydroxyl, but it was worse when it absorbed the medicine molecule without the activation groups.