Amide-derived P,O-ligand For Suzuki Cross-coupling And Their Application In Organic Synthesis

The Pd-catalyzed Suzuki-Miyaura (SM) cross-coupling reaction is one of the most efficient methods for the construction of C-C bond. The key advantages of the Suzuki cross-coupling are the mild reaction conditions and the commercial availability of the diverse boronic acids that are environmentally safer than the other organometallic reagents.In this thesis, we disclosed our research results on the novel class of amide-derived air-stable P,O-ligands for Suzuki cross-coupling and their application in organic synthesis. The thesis consists of three parts:In the first part, a brief review of Suzuki cross-coupling is provided.The second part focuses on the investigation of our P,O-ligands used for Suzuki cross-coupling. We have investigated the Suzuki cross-coupling reaction of aryl bromides at low catalyst loading and low temperature. We have synthesized some new P,O-ligands for the Suzuki cross-coupling reactions of aryl chlorides.In the third part, application of the amide-derived phosphine catalyzed Suzuki cross-coupling is presented. We have successfully used the Suzuki cross-coupling reaction as the key step for the synthesis of benzo porphycene anologs, which are difficult to prepare by using conventional Pd catalysts.Finally some experimental data and references are listed.