Study On Asymmetric Transfer Hydrogenation Of Acetophenone In Water

The world around us is chiral. Most of important components which constitute biological macromoleculars in the life system exist in one enantiomer. The life system has a very strong ability of identifying the chirality. Though the enantiomers of chiral molecular may have completely same physical and chemical properties, even same spectrum, there are still important differences between them .those are different activities in reaction with other chiral molecular. Therefore searching and researching the ideal synthesis method in which one enantiomer have more yield, especially the asymmetric synthesis that get the expected, single and pure enantiomer has been attracting considerable technical interest.With the knowledge of chiral molecular having been improved, more and purer chiral products were needed. Among them, alcohol with optical activity is extensively used in fine chemical engineering such as medicine, agrochemical, spicery etc. As a basic chiral semi-manufactured goods ,a-phenylethyl alcohol has a prominent position in the synthesis of chiral compounds.Because of its widely application, a-phenylethyl alcohol had been considered to be a prospective semi-manufactured goods with applied foreground.In this subject, the asymmetric hydrogenation reduction was conducted in water with noble metal while acetophenone being raw material and sodium formate being catalyst. The catalyst is a complex of [RuCl₂(PPh₃)₃] and TsNHCH₂CH₂NH₂. The influences of different factors such as temperature, acidity and responding time etc on the results were investigated. The optimal technique parameters were attained, which laid good foundation for further research .The results of the experiments indicate that it is viable that the asymmetric hydrogenation reduction is conducted in water when using sodium formate as reducing agent. The method has many advantages ,such assimplicity, moderate operation condition, short reaction time and high conversion. So it is necessary to do more researching at the foundation of this thesis and making the technique industrialization.