The Research Of Capsule Formulation,Preparation Technology As Well As Quality Of Meformin Hygdrochloride Enteric-coated A Tiny Capsules

This text emphasizes to discuss Meformin Hygdrochloride have become the biguanide type declining of diabetes sugar medicine of a double for choosing currently. According to the characteristic that Meformin Hygdrochloride mainly absorbed in small intestine and the bigger stimulating to stomach, we developed to have a special"target to medicine, the fixed position releases" characteristic to take orally the bowel that the diverse fixed position releases the medicine Meformin Hygdrochloride to dissolve a tiny pill capsule, can avoid medicine on the other hand in the stomach of release, ease side effect thus, on the other hand, the medicine releases in the bowel way, being advantageous to the absorption of medicine.The adoption leaves heart and wrap dress and build a grain of mechanism have tiny pill, assurance with 60-40 items microlite cellulose(MCC) blank pill core for the mother check, with 5% HPMC(5 cps) aqueous solution for glue to match, adopt a powder layer and accumulate legal system have tiny pill, again with the German (Eudraqit) humidity spread a body L30 Ds-55s in order to wrap a dress material to anticipate, make bowel to fill to pack a capsule after dissolving the tiny pill, make into bowel to dissolve a tiny pill capsule, and adopt purple outside cent light the intensity of light method built up the hydrochloric acid in the tiny pill Meformin Hygdrochloride and release a degree of measurement method.Pass a quality examination, dissolve tiny pill to carry amount of medicine according to the hydrochloric acid of the above method making Meformin Hygdrochloride bowels high, the content is 72.5%, sour win 2 hours release...