Synthesis, Photochemistry Characterization Of Cyclodextrin Derivatives

Parent cyclodextrin has a certain chemical stability, and it has a cavity which could be a combination of host or guest objects, but it has some limitations, therefore how using cyclodextrin as a structure to build all kinds of moleculors has become an important research topic in the cyclodextrin chemistry fields. A variety of enzymes have been simulated using cyclodextrin, such as transcriptase and nucleic acid enzyme. But using the cyclodextrin derivatives to simulate DNA photolyase havn't been reported.Three β-cyclodextrin derivatives,two cyclobutane pyrimidine dimers and two pyrimidine oxetane adducts are synthesized in the text. Photosensitized splitting of cyclobutane pyrimidine dimers and pyrimidine oxetane adducts are studied using β-cyclodextrin derivatives.1. Using compounds which can split dimers to modify β-cyclodextrinDifferent synthesis methods of β-cyclodextrin derivatives are compared, and the method we used have some merits. The derivatives are the just objets which are identified by ultraviolet-visible absorbtion, nuclear magneic resonance spectroscopy and other methods.2. Photosensitized splitting of cis-syn 1,3-dimethyl cyclobutane pyrimidine dimers by β-cyclodextrin-tryptophan and β-cyclodextrin-tyrosinePhotosensitized splitting of cis-syn 1,3-dimethyl cyclobutane pyrimidine dimers by β-cyclodextrin tryptophan and β-cyclodextrin tyrosine based on fluorescence quenching experiments and irradiation experiments determining the percentage of dimer was studied. It revealed that 1,3-dimethyl cyclobutane pyrimidine dimers are mainly splitted by e_aq resulted from two-photon ionization of β-cyclodextrin tryptophan and β-cyclodextrin tyrosine under...