Studies On The Synthetic Process Of The Third-Generation Cephalosporin, Ceftazidime

The development of β-lactam antibiotics and cephalosporins were briefly described in this paper, and the third-generation cephalosporin ceftazidime was also introduced. The synthesis of ceftazidime was studied. A synthetic route was designed and achieved, the synthetic method was modified, which make easier to process, and the yield was elevated. The product has of high purity and of good crystallization. The overall yield was 39.3%, which was synthesized from 7-ACA by five steps. The structure of ceftazidime was characterized by IR, ~1H-NMR and MS.