Studies On A New Anticongestive Heart Failure Drug Mozavaptan

The mechanisms of heart failure and the development of the anticongestive heart failure drugs were briefly described in this paper.Mozavaptan, an orally effective,nonpeptide arginine vasopressin V₂ receptor antagonist was introduced.Two synthetic routes were finished.The structures of Mozavaptan and the intermediates were identified by ¹H-NMR and MS.The yield of ethyl γ-N-(2-methoxycarbonylphenyl)-N-toluene-p-sulphon amidobutyrate increased by 16% after modifying the technics.Several factors including the ratio of start material,time,temperature were investigated.