The System Of Low-Molecular-Weight Chitosan Oral Cavity Films Has Craft And Quantity Standard Researches

According to modern medicine technique, we carried out a systematical study of the Low- Molecular-Weight Chitosan Oral Cavity Films, and combine to is an our country its development to six new medicines.The aim to solve the problem of water-insoluble of Chitosan. A water- soluble oligosaccharides of hydrolyzed Chitosan was prepared by using the method of directly oxidative degradation by H2O2. The structure of the oligosacchairides of hydrolytic Chitosan was determined by analysis of their IR spectroscopy, and polymerization degree was measured by high performance capillary electrophoresis(HPCE). The effects of concentration of H2O2, temperature and reaction time on the oxidative degradation were discussed respectively. The results showed that, hydrolyzation at 80～90℃,8～10% H2O2,and 0.5～1h,the production rate of water-soluble were 40%～45%. The method of oxidative degradation of Chitosan with H2O2 is convenient and effective for preparation of Chitosan with low-molecular weight.Orthogonal method was used for selecting the best comparison of Low-Molecular- Weight Chitosan Oral Cavity Films. Filtrated the additive of films by integrated evaluation, and then confirmed the prescription of films. We adopted PVA1788, CMC-Na conduct and action the material of film. The main medicine with the dosage comparison of the material of film is 1:2,PVA1788 and CMC-Na dosage comparison is 2:1,the dosage of the glycerin for 2.5%,add the mulitple of water as 20 times. Pass the many experimenting we settle inside layer film system the temperature of film as 60℃,the outside layer film system the temperature of film controls at 50℃.To control the quality of Low-Molecular-Weight Chitosan Oral Cavity Films, we established the qualitative and quantitative methods for medicinal materials and the Oral Cavity Films. The identification of Catechu in the medicinal materials and medicine by TLC, and contain to product inside Catechu and Borneclum Syntheticum were determined. We discussed the Low-Molecular-Weight in compound prescribe the Chitosan Oral Cavity Films a quantity for of deliquescence time limit, containing measurement settling method and measurement terms, first step making sure of films control standard.This article at produce the system have behind, need through circulate, store, apply the etc. link, the period is longer, for make apply in clinical hour the efficacy of medicine can meet the request to proceed to drugs the stability investigates, passing the constant temperature accelerates to experiment and the indoor temperature stays the kind experimented to study the proof the low molecular weight in compound prescribe Chitosan Oral Cavity Films has the good stability.