Synthesis And Investigation Of Functional Inorganic-Organic Nanocomposite And Its Application As Drug Delivery System

Mesoporous materials have many potential applications due to their large specific surface area, large pore volume, uniform pore size, controllable morphology, easily functionalized surface and highly ordered pore structure. The research on mesoporous materials is currently changing to the exploitation of their applications. One of the hot topics is the application of mesoporous materials in the controlled-release systems and bio/life sciences. In this thesis, we focused on the synthesis of multifunctional nanocomposites based on highly ordered mesoporous silica and their applications in controlled drug delivery, which have great theoretical and practical significations. The research relates to several hot fields, including life science, nano-science and technology and mesoporous materials science. The main contents of our work are summarized as follows:1. Synthesizing a novel multifunctional nanocomposites based on meosoporous silica SBA-15 with thermoresponsive PNIPA and magnetic nanoparticles Fe2O3 in the pore channels through nanocasting method and ultrasonication. The high surface area, highly ordered pore structure and multifunctional properties provide a fire-new method to fabricate a new controlled-release system.2. Employing hydrophilic FeCl2 as an additional precursor to fabricate powder SBA-15 with magnetic particles formed in situ via surfactant template sol-gel process and further developed the method to synthesize nano-coating PNIPA inside the SBA-15 channels. The in vitro test of IBU loading and release illustrated the system had a great potential use for thermo-responsive controlled drug-release.