Synthesis And Characterization Of Sucralose

After analysising kinds of synthesis methods of high intensity sweetener sucralose, in this paper we developed a new synthesis pathway. All the compounds were identified with elementary analysis, IR and 1H NMR. The conditions of synthesis were optimized using of the orthogonal test. The overall results as following:1,Developing a novel synthesis route for preparation of sucralose, which contain reacting sucrose with dibutyltin oxide to produce a sucrose distannoxane, acylating the sucrose distannoxane to produce a sucrose-6-ester, chlorinating the sucrose-6-ester to produce a sucralose-6-ester and deacylating the sucralose-6-ester to produce sucralose。2,The yields of preparation sucrose-6-ester and sucralose-6-ester were higher than previous methods in literature by optimizing each step reaction conditions. The yield of chlorination was increased by an improved Vilsimier reagent. The structure of the last compound was confirmed by FT-IR and NMR analysis.3,Our research emphasized industrialized synthesis, and the designed experiment project was practical in industry. First, we did experiment with pure grade reagent, and found the optimal synthesis route, and then we changed reagent pure material into industrial grade and did the experiment in the same way. It proved that we synthesized the object production-sucralose successfully. And then, we compared the configuration, content, and colour and luster of sucraloses synthesized with different material by infrared spectrometry, nuclear magnetic resonance spectrometry and high performance liquid chromatography. At last, we made sure that our route is feasible, and the sucralose synthesized with industrial grade material can meet the standard of FCC issued by America.