Synthesis Of 3-(2-aminoethyl)-phenol

3-(2-aminoethyl)-phenol is an important intermediate used for synthesizing somedyestuffs and pharmaceuticals. A synthesis of 3-(2-aminoethyl)-phenol starting from3-hydroxylbenzaldehyde, followed by condensation and catalytic hydrogenation reactions,was studied. The total yield 3-(2-aminoethyl)-phenol was 72.8% in a purity of 99.2%.Some rational technological parameters, related reaction mechanisms and reactionconditions were discussed for the first time .The structures and compositions of 3-(hydroxyl)-β-nitrostyrene and 3-(2-aminoethyl)-phenol were accomplished by spectralanalysis and chromatographic analysis.In the process of condensation reaction, it has been found that this reaction belongs toS_N1 mechanism, and according to this mechanism, some effective catalysts were found.This reaction is a reversible reaction, the yield was improved by means of improvingdevice and azeotropism.5%Pd-C, Raney-Ni, Cu were used in the process of catalytic hydrogenation andtheir best hydrogenation conditions were obtained, their catalyst's performances also werecompared, it has been found that 5%Pd-C, Raney-Ni were superior in catalytichydrogenation.The synthesis of 3-(2-aminoethyl)-phenol starting from 3-hydroxylbenzaldehyde,followed by condensation and reduction reactions, was convenient and mild.