Study On Michael Addition Of Amines To Ferrocenyl Chalcones

This paper described the synthesis of ferrocene derivatives. To beginning with, we utilized the techniques of solvent-free condition and ultrasonic irradiation to synthesis a series of ferrocenyl Chalcones (ferrocenylenones) via Aldol condensation of ferrocenyl ketones or aldehydes. After Michael addition of ferrocenylenones with amines, many P-amino ferrocenyl ketones are obtained, which no other references available in the literature reported to date.This thesis mainly focused on a new methodology for an intermolecular aza-Michael addition of amines to a, P-unsaturated carbonyl compounds. It was found that a facile Michael addition of ferrocenylenones with aliphatic amines in the absence of solvent and catalyst at room temperature could afford P-amino ferrocenyl ketones rapidly in high yields by using ultrasound irradiation or grinding at solid state. However, aromatic amines did not undergo the conjugate addition at all, and the reactions under existing methods did not proceed or took place in low yield after a long reaction time. Apart from experimental simplicity and selectivity, the advantages of this methodology are the rapid, environmentally benign and less expensive processes, which will contribute to the progress of green chemistry.