Prepration And Characterization Of P-acetamidobenzoylate Chitosan And P-benzoylaminobenzoylate Chitosan

Chitosan (CTS), a biocompatible, biodegradable, non-toxic polymer, shows poor affinity for organic solvents. Two novel types of chitosan derivatives are synthesized in this work, which both show good water solubility and have good property of ultraviolet absorption and surface activity. The product are characterized by IR spectrum,UV spectrum and elemental analysis.1 (1) Prepration of p-acetamidobenzoylate chitosanFirst, purify the p-aminobenzoic acid. P-amidobenzoic acid is dissolved in water under stirring at 60℃. Then acetic anhydride (10ml,0.106mol) are rapidly added under intense stirring. The reaction time was 30 minute. After cooling to room temperature, the precipitate is collected on a filter and dried under vacuum at 60℃. P-acetamidobenzoic acid is dissolved in aether under room temperature, then put excessive SOCl2 into solution. So this novel type of chitosan derivative is prepared by chitosan reacting with the solution of p-acetamidobenzoyl chloride in acetic acid under high-intensity ultrasound. After reaction, put acetone into the solution and filtration, vacuum drying. The optimal reaction conditions, the reaction temperature is 25℃, the reaction time is 1.5 hours, quality ratio is 1:2.(2) Characterization of p-acetamidobenzoylate chitosanStructure of the product is characterized by IR spectrum,UV spectrum and elemental analysis. Chitosan derivative IR spectra display new absorpation peak at 1734cm-1,1629 cm-1,1531 cm-1, corresponding to the c=o stretching mode of the carboxyl-function and C=C of benzene function. The result of UV shows that the product has good property of ultraviolet absorption at 273nm. The product has capacity of surface activity, solubility.2 (1) Prepration of p-benzoylaminobenzoylate chitosanFirst, the preparation of p-benzoylaminobenzoic acid, which is prepared by p-aminobenzoic acid reacting with benzoyl chloride. P-benzoylaminobenzoic acid is dissolved in aether under room temperature, then put excessive SOCl2 into solution. So Chitosan derivative carrying p-benzoylaminobenzoylate groups is prepared by chitosan reacting with the solution of p-benzoylaminobenzoylate chloride in acetic acid system under high-intensity ultrasound. After reaction, put acetone into the solution and filtration, vacuum drying. The optimal reaction conditions, the reaction temperature is 25℃, the reaction time is 1.5 hours, quality ratio is 1:3.(2) Characterization of p-benzoylaminobenzoylate chitosanThe identity of the p- benzoylaminobenzoylate chitosan is confirmed by FT-IR spectrometry, UV spectrometry and elemental analysis. Chitosan derivative IR spectra display new absorpation peak at 1707cm-1,1605 cm-1,1503cm-1, corresponding to the c=o stretching mode of the carboxyl-function and C=C of benzene function. The result of UV shows that the product has good property of ultraviolet absorption at 283nm. The product has capacity of surface activity, solubility.3 (1) Design formula 1 and formula 2 of the emulsion - cream milk which components contain chitosan derivative.(2) Produce the cream cosmetics, which is characterized by UV spectrophotometer. The result of UV shows that the cosmetic product containing derivatives has good property of ultraviolet absorption from 270nm to 300nm ,the cosmetic products without adding chitosan derivatives have poor property of ultraviolet absorption from 250nm to 300nm. The experimental results show that the chitosan derivative open new perspectives as sun screener.